Monday, June 07, 2021

The Science Suggests a Wuhan Lab Leak

 

The Science Suggests a Wuhan Lab Leak







Thanks to SmallDeadAnimals I found this article.  Since it is behind a paywall and I am a subscriber to WSJ I copied the article out full to allow you to read this if you are not a subscriber to the WSJ.

J

The Covid-19 pathogen has a genetic footprint that has never been observed in a natural coronavirus.

By

Steven Quay and

Richard Muller

June 6, 2021 11:59 am ET .
SHARE
Listen to Article ( 6 minutes)
00:00 / 06:23
1x
This article is in your queue.

Illustration: Martin Kozlowski

.

The possibility that the pandemic began with an escape from the Wuhan Institute of Virology is attracting fresh attention. President Biden has asked the national intelligence community to redouble efforts to investigate.

Much of the public discussion has focused on circumstantial evidence: mysterious illnesses in late 2019; the lab’s work intentionally supercharging viruses to increase lethality (known as “gain of function” research). The Chinese Communist Party has been reluctant to release relevant information. Reports based on U.S. intelligence have suggested the lab collaborated on projects with the Chinese military.

Opinion: Potomac Watch
Reading Dr. Anthony Fauci's Emails
00:00 / 24:20
1x
.

But the most compelling reason to favor the lab leak hypothesis is firmly based in science. In particular, consider the genetic fingerprint of CoV-2, the novel coronavirus responsible for the disease Covid-19. 

In gain-of-function research, a microbiologist can increase the lethality of a coronavirus enormously by splicing a special sequence into its genome at a prime location. Doing this leaves no trace of manipulation. But it alters the virus spike protein, rendering it easier for the virus to inject genetic material into the victim cell. Since 1992 there have been at least 11 separate experiments adding a special sequence to the same location. The end result has always been supercharged viruses.

A genome is a blueprint for the factory of a cell to make proteins. The language is made up of three-letter “words,” 64 in total, that represent the 20 different amino acids. For example, there are six different words for the amino acid arginine, the one that is often used in supercharging viruses. Every cell has a different preference for which word it likes to use most.

Advertisement

In the case of the gain-of-function supercharge, other sequences could have been spliced into this same site. Instead of a CGG-CGG (known as “double CGG”) that tells the protein factory to make two arginine amino acids in a row, you’ll obtain equal lethality by splicing any one of 35 of the other two-word combinations for double arginine. If the insertion takes place naturally, say through recombination, then one of those 35 other sequences is far more likely to appear; CGG is rarely used in the class of coronaviruses that can recombine with CoV-2.

In fact, in the entire class of coronaviruses that includes CoV-2, the CGG-CGG combination has never been found naturally. That means the common method of viruses picking up new skills, called recombination, cannot operate here. A virus simply cannot pick up a sequence from another virus if that sequence isn’t present in any other virus.

Although the double CGG is suppressed naturally, the opposite is true in laboratory work. The insertion sequence of choice is the double CGG. That’s because it is readily available and convenient, and scientists have a great deal of experience inserting it. An additional advantage of the double CGG sequence compared with the other 35 possible choices: It creates a useful beacon that permits the scientists to track the insertion in the laboratory.

Now the damning fact. It was this exact sequence that appears in CoV-2. Proponents of zoonotic origin must explain why the novel coronavirus, when it mutated or recombined, happened to pick its least favorite combination, the double CGG. Why did it replicate the choice the lab’s gain-of-function researchers would have made?

Advertisement

Yes, it could have happened randomly, through mutations. But do you believe that? At the minimum, this fact—that the coronavirus, with all its random possibilities, took the rare and unnatural combination used by human researchers—implies that the leading theory for the origin of the coronavirus must be laboratory escape.

When the lab’s Shi Zhengli and colleagues published a paper in February 2020 with the virus’s partial genome, they omitted any mention of the special sequence that supercharges the virus or the rare double CGG section. Yet the fingerprint is easily identified in the data that accompanied the paper. Was it omitted in the hope that nobody would notice this evidence of the gain-of-function origin?

But in a matter of weeks virologists Bruno Coutard and colleagues published their discovery of the sequence in CoV-2 and its novel supercharged site. Double CGG is there; you only have to look. They comment in their paper that the protein that held it “may provide a gain-of-function” capability to the virus, “for efficient spreading” to humans.

There is additional scientific evidence that points to CoV-2’s gain-of-function origin. The most compelling is the dramatic differences in the genetic diversity of CoV-2, compared with the coronaviruses responsible for SARS and MERS.

Advertisement

Both of those were confirmed to have a natural origin; the viruses evolved rapidly as they spread through the human population, until the most contagious forms dominated. Covid-19 didn’t work that way. It appeared in humans already adapted into an extremely contagious version. No serious viral “improvement” took place until a minor variation occurred many months later in England.

Such early optimization is unprecedented, and it suggests a long period of adaptation that predated its public spread. Science knows of only one way that could be achieved: simulated natural evolution, growing the virus on human cells until the optimum is achieved. That is precisely what is done in gain-of-function research. Mice that are genetically modified to have the same coronavirus receptor as humans, called “humanized mice,” are repeatedly exposed to the virus to encourage adaptation.

The presence of the double CGG sequence is strong evidence of gene splicing, and the absence of diversity in the public outbreak suggests gain-of-function acceleration. The scientific evidence points to the conclusion that the virus was developed in a laboratory.

Dr. Quay is founder of Atossa Therapeutics and author of “Stay Safe: A Physician’s Guide to Survive Coronavirus.” Mr. Muller is an emeritus professor of physics at the University of California Berkeley and a former senior scientist at the Lawrence Berkeley National Laboratory

Fauci and Top US Doctors Caught! They CONSPIRED to Disqualify Hydroxychloroquine as COVID Treatment

 

IT’S WORSE THAN WE THOUGHT! Fauci and Top US Doctors Caught! They CONSPIRED to Disqualify Hydroxychloroquine as COVID Treatment — MILLIONS DEAD AS A RESULT



You  wanted to know if you could trust your scientists?  Well we can never go there again.  I want you to think about the global warming pusded by scientists.  Once politics enters into the science it becomes a religion.

J

Sunday, June 06, 2021

Saturday, June 05, 2021

Mundo Loco: NYC Psychiatrist Tells Yale Audience She Fantasizes About Shooting White People

 

NYC Psychiatrist Tells Yale Audience She Fantasizes About Shooting White People in the Head and Burying Their Body with Her Bloody Hands






Wow!  Do you have to be crazy to be a Psychiatrist?  Unbolted and loose on the streets.  It is time to pull her ticket and have her committed.

J

REVEALED: Federal Government Funneled $123 Million and Pentagon Funneled $39 Million to Daszak’s EcoHealth Alliance

 

REVEALED: Federal Government Funneled $123 Million and Pentagon Funneled $39 Million to Daszak’s EcoHealth Alliance – Group that Funded Coronavirus Research in Wuhan



No one thinks that these guys are not smart scientists we just find that they are morally challenged and duplicitous when it comes to their decisions, enhanced function of viruses, trying to cover their financial tracks and hiding their work in China.  The Lawsuits are just over the horizon and things will get very interesting.

J

Mundo Loco: Cargill Taps Startup Producing Smart Cow Masks To Trap Methane Burps

 

Cargill Taps Startup Producing Smart Cow Masks To Trap Methane Burps



We have to have this on the record as crazy thinking.  Guys, lets get back to simple questions like how many angels can dance on the head of a pin.

Our business leaders are lost in the religion of climate change.  

J



Friday, June 04, 2021

Scientist At Center Of Lab-Leak Controversy Put In Charge Of The Lancet's Task Force To Investigate COVID Origin

 

Scientist At Center Of Lab-Leak Controversy Put In Charge Of The Lancet's Task Force To Investigate COVID Origin


If you wonder why so many people are skeptical about the scientists here is another example of the problem.  These guys think they are fooling us, perhaps they are for most of the population but if you have a memory and follow the news you have to shake your head in disbelief.

J


The Net Zero Cure Is Far Worse Than The Disease

  The Net Zero Cure Is Far Worse Than The Disease https://www.zerohedge.com/political/net-zero-cure-far-worse-disease We are now going to fa...